Safe houses

IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development.

The IMP3 RNA-binding protein is associated with metastasis and poor outcome in human cancer. Using solid cancer transcriptome data, we found that IMP3 correlates with HMGA2 mRNA expression. Cytoplasmic IMP3 granules contain HMGA2, and IMP3 dose-dependently increases HMGA2 mRNA. HMGA2 is regulated by let-7, and let-7 antagomiRs make HMGA2 refractory to IMP3. Removal of let-7 target sites elimina...

Green houses.

We designed a web server for the analysis of biosynthetic capacities of metabolic networks. The implementation is based on the network expansion algorithm and the concept of scopes. For a given network and predefined external resources, called the seed metabolites, the scope is defined as the set of products which the network is in principle able to produce. Through the web interface the user c...

Halfway Houses

Merging Auction Houses

In this paper, we study the incentives for market concentration of (online and traditional) auction houses. Would sellers and buyers be better off if two separate auction houses merged? We suppose that each auction house has a separate clientele of sellers and buyers. Sellers value their (identical) units at 0, while buyers have independent private values. Each auction house uses an ascending a...

Half-Way Houses

As a mental health worker who has been watching the working out of the Mental Deficiency Acts for some years now, I would allow myself some honest criticism in the hope that it may be constructive. I often wonder, allowing for the still serious lack of institutional accommodation in most areas, whether it is really necessary to make such provision for some of the high grade patients who are at ...